Test

Acta Endocrinol (Copenh) 1976 Dec;83(4):856-64 Related Articles, Links


Effect of an anabolic steroid (metandienon) on plasma LH-FSH, and testosterone and on the response to intravenous administration of LRH.

Holma P, Adlercreutz H.

Plasma levels of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) as well as the response of LH and FSH to the intravenous administration of 100 mug of luteinizing hormone releasing hormone (LRH) were measured in 16 well-trained athletes (mean age 30 years) before and after 2 months of daily oral intake of 15 mg of metandienon, and anabolic steroid (Anabolin, 17 alpha-methyl-17beta-hydroxy-1,4-androstadien-3-one, Medica, Finland). All athletes continued to train regularly, just as they had done for several years. During administration of metandienon the mean plasma testosterone level fell 69%, from 29.4 +/- 11.6 nmol/1 to 9.1 +/- 7.5 nmol/1. The mean plasma levels of LH and FSH also fell significantly (P less than 0.001 and P less than 0.01, respectively), both about 50%. Because LH and FSH levels were low after administration of the steroid the maximum stimulation values after LRH administration were also lower than pre-treatment values although the mean increments did not differ significantly before and after administration of the anabolic steroid. However, after treatment, the FSH response curve had a biphasic pattern in most subjects, with peaks at 10 to 20 and 50 to 60 min after the iv injection of LRH. Administration of LRH after the treatment period had no effect on FSH secretion in two subjects and no effect on LH secretion in one. Our results show that administration of an anabolic steroid causes a pronounced lowering of plasma levels of testosterone, LH and FSH but causes no gross alteration in the response of LH secretion to stimulation by LRH. The reason for the biphasic response pattern of FSH to LRH administration in most subjects is not known.

Thanks for the article:

Ah...now lets delve into mathematics, shall we:

First: 15mg I said 10mg.

15mg lowered test levels by 69%.

LH and FSH by 50%

Now, lets apply some simple math.

15mg dball will be excreted in.......15mg /average 4hr T-life = Average of:

15mg ------ 7.5mg ------ 3.75mg ------ 1.875mg ------- 0.9875mg

So after overgoing 4 Half-life conversion(I'm not even counting the fact that excercise INCREASES dball excretion btw...by quite a margin)

It took the men roughly 16hrs to get to within reasonable Dball(Androgen concentrations), about roughly 1mg.
In case you're wondering, I'm mathematically comparing the suppression seen by 15mg and 10mg of dball in reference to blood levels and time.
(I'm not even going to state that the study doesn't even say they took it all in the AM....they probably didn't. But I'm feeling charitable today so I'll give you guys a break. I'll stipulate they took i all in the AM)

Now, for 10mg.

10mg ------- 5mg --------- 2.5mg --------1.25mg ---------0.625mg

Linearly speaking, it took 3.4 half-lives or roughly 13.6 hrs to get to 1mg.

Thats 85% of the 15mg Dball study.13.6hrs/16hrs = 0.85

So, Free Test should then become 58.7% decrease and LH and FSH 42.5%

This is using the 4hr half-life. The gold standard for dball.

Now lets add Arimidex and Clomid to the mix shall wee?

Arimidex will INCREASE the decrease in test seen by the AM dball administration via less testosterone being converted into estrogen via the aromatase enzyme.

By how much normally? 58% increase in test.(Look the abstracts up. They've been posted a zillion times...I'm not going to do it for you) And also a large decrease in estrogen mind you.

OK. So now, the 58.7% reduction in test seen for the 10mg Dball is FURTHER reduced to (58.7 * (1-0.58)) = 24. 65%

So, low and behold 10mg AM dball+arimidex BY THEMSELVES cause only a 24.65% drop in test levels. Compare this to the 58.7% seen in the Dball only group. This is why arimidex MUST be used, and why I have said it a zillion times.

Now lets add Clomid and HCG shall we? Good. The math/pharmacology class is proceeding nicely. Clomid will boost both FSH and LH, and HCG will cause yet ANOTHER surge in endo Test levels through its effects on the Leydig cells.
And low and behold, since we are on arimidex, the increase seen will be test only because the aromatase enzyme is being blocked by the arimidex from converting the test surge caused by the HCG into estrogen..

By how much?

I don’t know. But what I do know, is that the 24.65% reduction in testosterone will be reduced even further(By the HCG and the Clomid), and the LH values as well to well less than 45%.

Gee whiz…..am I starting to kill of all the SCIENTIFIC doubters…….. LOL

From my bloodwork(and from other peoples) NOT Clomid and HCG studies, I came up with an INCREASE in Test levels over pre-main cycle levels and an almost normal LH.(Roughly 80-90%) of normal.

The problem was THAT I could not extrapolate info from ANY HCG and Clomid studies b/c they were not on the AM Dball routine.

So, I had to test it on myself and get bloodwork done.

And it WORKED. Yes, it WORKED. My test levels INCREASED while on the Dball AM bridge while my LH slowly recuperated, when compared to pre-main cycle levels.

Again, the dball bridge ONLY works if you take the dball in accordance with your bodies circadian rhythm. If you don’t go to sleep at a certain time and sleep for 8 hours and wake up at a certain time(and then take the 10mg dball right away) CONSISTENTLY, The Dball bridge will then not work properly.

As an addendum, if you actually want to BOOST your LH levels to normal while on the bridge, use 25mg proviron 6-8 weeks before your AM Dball Bridge post-cycle therapy, and you will then be able to increase LH levels to normal.(I already proved this with studies at AF…go look them up. Its in the Hall of Fame) You obviously must use the proviron during the Dball bridge as well.

So, the Bridge becomes:

(6-8 weeks) before end of Main cycle: Start 25mg Proviron

End Main Cycle.

AM Dball Bridge cycle: 8 weeks

#1.Start Bridge at 10mg Dball in the AM upon waking up.
#2 Make damn sure you take the 10mg dball at the same damn
time every day. As soon as you wake up. This wake up time
(if 8 or 9 or 10 AM) must be used for the rest of
the bridge(8 weeks)(Circadian Rhythm is VERY important to
the success of the bridge)
#3 Proviron at 25mgs/day(LH booster)
#4 Arimidex at 1mg ED or more.(2mg is as high as I would go).
#5 HCG at 5000IU’s 2X/week on Weeks 5,6,7,8(Endo Test
Booster)
#6 Clomid at 300mgs Day 1, and then 100mgs/day from then on
until the end of the bridge(LH and FSH Booster)

End result: Test levels HIGHER than pre-main cycle levels…by roughly 20% (Most definately in the normal range), and a normal LH function.
Even better: NO DAMN MUSCLE LOST while coming off the bridge.
Almost EVERY single post-cycle therapy out there causes you to lose muscle(Except for GH/Slin/IGF-1). PERIOD. Well guess what? This one doesn’t.

There, I scientifically and mathematically wise PROVED that the AM Dball Bridge works.

Bardzo dobry art ... problemem pozostaje tylko cena tego sposobu ... dyskusyjna pozostaje takze kwestia czy jest to mniej szkodliwe niz - po prostu - zwiekszenie dawki Metanabolu ...

Wow.. Uriel spodoba ci sie to Bridge z d-bol'a :D Tylko ten arimidex.. możnaby z cynkiem pokombinować ;)

Kulfa nie chce mi się czytać - naje.bany jestem zdrowo - idę po piwo raz jeszcze...

Zaraz przeczytam! Ja lubie mostki z Dbolu.

Spice - co jest mniej szkodliwe? Ja jestem za 10mg Dbol'u rano przez 8 tygodni bez dokładania Anastrozolu.

Elite coś Ty wyciągnął - ja tu Spicola zalewam pytaniem a to z roku 2003. Weeeeeeeeeeee!