"Monoamines (biogenic amines)
Norepinephrine (Noradrenaline; NA) and Epinephrine (Adrenaline; AD)
Precursors:
L-
Tyrosine (a) -> L-DOPA, (b) -> dopamine, (c) -> noradrenaline, (d) -> adrenaline
Synthesising enzymes:
(a) tyrosine hydroxylase, (b) L-aromatic amino-acid decarboxylase, (c) dopamine-beta-hydroxylase, (d) phenylethanolamine-N-methyl transferase
Metabolising enzymes:
MAO and COMT
Metabolites:
Vanillylmandelic acid (VMA) and 3-methoxy-4-hydroxyphenylglycol (MHPG)"
"The action of noradrenaline is terminated by diffusion from the site of action, re-uptake back into the presynaptic nerve ending where it is inactivated by the enzyme Monoamine Oxidase in mitochondria or metabolism locally by the enzyme Catechol-O-Methyl-Transferase. "
"Strong coffee, much strong coffee, is what awakens me. Coffee gives me warmth, waking, an unusual force and a pain that is not without very great pleasure."